Gene expression modification in lungs of rats exposed to TiO2 by inhalation

In this work we study the pulmonary toxicological properties of titanium dioxide using molecular toxicological approache. For this, we exposed Sprague Dawley rats by inhalation. Lung samples have been collected up to 180 days after the end of exposure and transcriptomics analysis were performed.本研究采用分子毒理学方法，探究二氧化钛的肺部毒理特性。为此，我们通过吸入方式对斯普拉格-道利（Sprague Dawley）大鼠进行染毒。于染毒结束后最长180天采集肺组织样本，并开展转录组学分析。