Metabolic response to antibiotic treatment.

aSignificant metabolites for S. aureus antibiotic treatment response common human S. aureus sepsis and mice infected with MRSA and MSSA, and human S. aureus sepsis and in vitro grown MRSA or MSSA.
bRefers to response to antibiotic treatment, where ↑/↓ indicates a higher/lower metabolite concentration in samples with effective treatment compared to samples with ineffective treatment (for in vitro experiments and mice infection) and in late time point, 144 h-2 weeks after admittance, compared to acute phase infection samples, 0–24 h after admittance (for human sepsis).
cRetention index for all metabolites.
dConcentration obtained from direct quantification of the 7 metabolites in a subset of the S. aureus samples shown both for samples in the acute phase (0 h) and in the late phase (144 h).