The InsP7 phosphatase Siw14 regulates levels of inositol pyrophosphates and affects activity of general stress transcription factors Msn2 and Msn4. The InsP7 phosphatase Siw14 regulates levels of inositol pyrophosphates and affects activity of general stress transcription factors Msn2 and Msn4

Cells missing the InsP7 phosphatase Siw14 were exposed to osmotic and oxidative stress and the transcriptional response compared to that in a wild-type strain. The data show that the Siw14 delete strain has an elevated stress reponse in log growth conditions, but still mounts a robust response to acute stress. Overall design: The study includes 5 experiments that measure the impact that the InsP7 phosphatase Siw14 has on the Environmental Stress Response (ESR) in budding yeast