Jiangya Kangxian Formula attenuates Cardiac Remodeling induced by Hypertension in Spontaneous Hypertensive Rat through modulating Mitochondrial Dysfunction

Kangxian formula (KXF), composed of 5 traditional Chinese distinct herbs including Panax Notoginseng, Radix Salviae, Spatholobus Suberectus Dunn, Hedysarum Multijugum Maxim and Citri Grandis Exocarpium, is a proved recipe showing promising outcomes in treating hypertension and cardiac remodeling in clinic. However, the effect of longterm treatment with KXF in such a condition and the related molecular mechanisms remain ambiguous. Here, we evaluated the effect of KXF on the gut microbiota and the prevention of hypertension and cardiac remodeling. Spontaneously hypertensive rats (SHRs) administered intragastrically with KXH (KXF high-dose,9.6g/kg) or distilled water