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Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells

NIAID Data Ecosystem2026-03-11 收录

干细胞心脏分化

环境毒素发育毒性

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122003 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2019-03-26

干细胞心脏分化

Wnt信号通路调控

Efficient directed cardiac induction of human embryonic stem cells requires an intermediate inhibition of WNT signaling, shortly after the initial induction of mesoderm. To reveal the significance of

NIAID Data Ecosystem70

table_genes_counts_RPKM

干细胞心脏分化

RNA-seq基因表达

This table contains all the counts and RPKM values of genes identified on RNA-seq of hESC cardiac differentiation, including Ribosome-free and Polysome-bound fractions.

NIAID Data Ecosystem40

Comparative cardiac induction time-courses using WT, EOMES KO, and EOMES TET-ON human ES cells

干细胞心脏分化

EOMES基因

This study compares cardiac induction time-courses using (i) wild-type hESCs subjected to a standard directed differentiation protocol, (ii) EOMES knockout hESCs subjected to the same protocol, and (i

NIAID Data Ecosystem20

Cardiac precursor differentiation from hESCs by lentiviral promoter drug selection. Homo sapiens

干细胞心脏分化

转录组剪接分析

Several of the essential core transcriptional control elements in human embryonic stem cells (ESCs) have been identified, but the production and function of alternative isoforms in self-renewal, pluri

NIAID Data Ecosystem50

Analysis of downstream effects of endogenous WNT signaling during cardiac differentiation of human ES cells. Homo sapiens

干细胞心脏分化

Wnt信号通路调控

WNT signaling inhibition at an intermediate stage of differentiation is a key requirement for cardiac induction of human ES cells, suggesting that endogenous WNT activity interferes with cardiomyocyte

NIAID Data Ecosystem40

Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells

资源简介：

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