The comparison of Macaca fascicularis gut microbiota to other mammalians and its changes under type 2 diabetes condition

The Macaca fascicularis model is widely used in scientific research and drug development as its genetics is very closed to human being. Comparing its similar feeding habits with human, the characteristics of Macaca fascicularis gut microbiota and its similarities to human and other mammalians remains unknown and knowledge of the functional interplay between the gut microbiota and host physiology in Macaca fascicularis is also limited. In our study, faecal samples from 20 Macaca fascicularis individuals were applied to metagenomic sequencing to construct the first gene catalogue of Macaca fascicularis gut bacteria. Totally 1.9 million non-redundant bacterial genes were identified.