A Drosophila melanogaster model of urolithiasis was supplemented with a microbial therapeutic to assess its efficacy in mitigating stone formation. Whole flies were sequenced with 16S rRNA gene sequen
Expression of mutant lamins in human muscle causes muscular dystrophy. We have generated a drosophila model that expresses mutant lamins, modeled after those that cause disease in humans. We used affy
We analyzed gene expression in lung tissue from Calca+/- and WT rats using RNA-seq, and subsequent Gene Ontology (GO) analysis showed that nucleus and cytoplasm expression pathways were significantly
Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-γ-dependent inflammatory disease dominated by fatty degeneration and necros
Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and the accumulation of somatic mtDNA mutations is implicated in aging and common diseases. However, the mechanisms that
