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ARID1A regulates RNAPII pausing in ovarian clear cell carcinoma

NIAID Data Ecosystem2026-03-10 收录

卵巢透明细胞癌转录调控

RNA聚合酶II暂停调控

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https://data.mendeley.com/datasets/7ch3xx79gv 数据链接链接失效反馈

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Immunoblots were made to check knock-down levels for ARID1A and ARID1B, overexpression and time-course regulation for ARID1A and ARID1B, and protein levels for pausing factors as RNAPII, NELF and SPT5.

应用场景：

创建时间：

2018-05-24

白血病转录调控

RNA聚合酶II暂停调控

1Sheng Yushou Center of Cell Biology and Immunology, Department of Genetics and Developmental Biology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China

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Negative Elongation Factor (NELF) regulation of muscle progenitor expansion assessed via Precision Run-On Sequencing (PRO-seq)

平滑肌细胞转录调控

RNA聚合酶II暂停调控

Assessment of promoter-proximal RNA polymerase II pausing in wild type and NELF-B KO (muscle stem cell-specific deletion) myoblasts PRO-seq: 2 biological replicates each for WT and NELF-B KO; RNA-seq:

NIAID Data Ecosystem20

H3K4me2/3 modulate the stability of RNA polymerase II pausing (ChIP-Seq)

RNA聚合酶II暂停调控

组蛋白甲基化转录调控

Modifications of histones are intricately linked with the regulation of gene expression, with demonstrated roles in various physiological processes and disease pathogenesis. Methylation of histone H3

NIAID Data Ecosystem20

m6A RNA methylation regulates promoter proximal pausing of RNA Pol II (ChIP-Seq)

m6A表观转录组学

RNA聚合酶II暂停调控

The transcriptional regulation is often controlled by the epigenetic modifications or by chromatin associated proteins. To understand this regulation, chromatin immunoprecipitation (ChIP) followed by

NIAID Data Ecosystem30

The NELF pausing checkpoint mediates the functional divergence of Cdk9. The NELF pausing checkpoint mediates the functional divergence of Cdk9

转录调控机制

RNA聚合酶II暂停调控

Cdk9 is an essential transcriptional kinase that is conserved across distant eukaryotes, but we previously found that acute inhibition of Cdk9 causes different transcriptional phenotypes in NELF-conta

NIAID Data Ecosystem20

ARID1A regulates RNAPII pausing in ovarian clear cell carcinoma

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