Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans

Single cell analysis of older, hyposmic adult and normosmic adult olfactory epithelium yields evidence for inflammation-associated changes in the OE stem cells of presbyosmic patients Overall design: Single cell 3' RNAseq of olfactory epithelium from 6 adult human patients (3 normosmic subjects, based on psychophysical olfactory assessment, with SIT scores 34 – 37; 3 presbyosmic subjects, SIT scores 11 - 29 and age >65 years) using the 10X Genomics Chromium platform and sequenced on Illumina Nextseq 500.