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Intramolecular Aromatic Nucleophilic Substitution of the Benzimidazole-Activated Nitro Group

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https://figshare.com/articles/dataset/Intramolecular_Aromatic_Nucleophilic_Substitution_of_the_Benzimidazole_Activated_Nitro_Group/3356977
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资源简介:
A wide range of 2-(2-nitrophenyl)-1H-benzimidazoles undergo high-yielding intramolecular SNAr of nitrite with N-pendant alkoxides under mild conditions (DMF, rt). When this operationally simple process is carried out at elevated temperatures in the presence of excess NaH, the initially formed SNAr products are converted to the corresponding N-vinyl-substituted 2-(2-hydroxyphenyl)-1H-benzimidazoles via base-catalyzed isomerization.
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2016-05-07
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