Gene regulatory markers in pregnant, term non-labouring, labouring, and postpartum myometrium.. Gene regulatory markers in pregnant, term non-labouring, labouring, and postpartum myometrium.

We have generated genome-wide binding and expression datasets in uterine smooth muscle (myometrium) from murine models of pregnancy and labour. ChIP-seq and total RNA-seq experiments were conducted to evaluate changes in the genomic and transcriptomic landscape of the myometrium prior to, during, and after labour onset. Overall design: Examination of total RNA and POL2 enrichment in pregnant and labouring myometrium; examination of euchromatin-associated histone marks (H3K27ac, H3K4me3) in pregnant, term non-labouring, labouring, and postpartum myometrium