Dataset S2. Proteins identified by Scaffold in outer membrane vesicles produced by E. cloacae in the presence and absence of murine norovirus.

Norovirus interactions induce widespread changes in gene expression in E. cloacae. These changes in gene expression occur alongside changes in the surface architecture of the bacterium and an increased production in outer membrane vesicles. While vesicle production is increased, the size of vesicles are smaller. Shifts in vesicle size are correlated with changes in vesicle content. To determine if murine norovirus interactions altered the content of membrane vesicles produced by E. cloacae, proteomic analysis of vesicles produced in the presence and absence of the virus was performed.