Single cell transcriptomic profile of thymic CD21-CD35- B cells in human neonates

We have demonstrated that thymic B cells, and more concretely CD21-CD35-, are highly heterogeneous in human neonates. To unravel the heterogeneity, we sorted and analyzed the transcriptome by single-cell RNA sequencing the CD21-CD35- B cell subset in six human donors of 4 days and 4 months old. Examination of single cell transcriptome of thymic CD21-CD35- B cells in human neonates by single cell RNA-sequencing.