Additional file 1 of The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis

Additional file 1: Table S1. Search strategies by data sources. Table S2. Cognitive tests employed in each trial by their corresponding cognitive domain. Table S3. Detailed description of the risk of bias (RoB) for the individual studies. Table S4. Sensitivity analyses for each of the six cognitive domains. Fig. S1. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the episodic memory. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S2. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the processing speed. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S3. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the attention. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S4. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the visuospatial function. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S5. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the global cognition based on the studies from countries where the blood level of DHA + EPA is very low. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S6. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the executive function based on the studies from countries where the blood level of DHA + EPA is very low. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S7. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the global cognition based on the studies from countries where the blood level of DHA + EPA is not very low. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S8. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the executive function of the people with mild cognitive impairment. (a) daily intake of n-3 PUFA; (b) total amount of n-3 PUFA taken during the study period; (c) daily intake of docosahexaenoic acid (DHA); (d) daily intake of eicosapentaenoic acid (EPA); (e) ratio of DHA to EPA taken. Fig. S9. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the global cognition of the cognitively normal individuals. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S10. Dose-response meta-analyses for the association between n-3 polyunsaturated fatty acids (PUFA) and the executive function of the cognitively normal individuals. (a) duration of intervention; (b) daily intake of n-3 PUFA; (c) total amount of n-3 PUFA taken during the study period; (d) daily intake of docosahexaenoic acid (DHA); (e) daily intake of eicosapentaenoic acid (EPA); (f) ratio of DHA to EPA taken. Fig. S11. Funnel plots of meta-analyses between n-3 polyunsaturated fatty acids and the (a) global cognition, (b) episodic memory, (c) executive function, (d) processing speed, (e) attention, and (f) visuospatial function.