Adverse events reported in the studies in healthy volunteers.

Treat = treatment; NR = not reported; RR = relative risk; CI = confidence interval; IV = intravenous; AE = adverse effects.
aas reported by authors.
breason dropout not reported.
cvery limited reporting adverse events.
dbackache.
edizziness; lightheadedness.
foverall percentage (all groups).
grash; dizziness and tachycardia.
hmoderate headache with increasing intensity; repeated vomiting.
imoderate rash (n = 3); mild nausea.
jliver function and hematologic abnormalities.