Burkitt-like lymphoma with 11q aberration: A germinal center derived lymphoma without ID3-TCF3-CCND3 pathway deregulation [ONCOSCAN]

Burkitt-like lymphoma with 11q aberration (BLL-11q) is a new provisional category in the 2016 WHO classification. The limited number of reported cases does not allow to define whether this is a specific entity or it is a particular variant of other recognized categories such as Burkitt or diffuse large B-cell lymphoma. The genetic alterations involved in the pathogenesis of BLL-11Q are not known. The aim of this study was to perform a complete genetic characterization of Burkitt like lymphoma with 11q aberration. Eleven cases (8 males and 3 females; mean age: 15 years, range 8-37) with consensus diagnosis were analyzed by fluorescence in situ hybridization, copy number (CN) array and targeted sequencing analyses of genes associated with B-cell lymphoma pathology. BLL11q_ONCOSCAN