Structure and cell cycle-regulated transcription of the human cyclin A gene.
收藏PubMed Central1994-06-07 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC44021/
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资源简介：
Cyclin A is a cell cycle regulatory protein that functions in mitotic and S-phase control in mammalian somatic cells. Its deregulated expression may have a role in cellular transformation. We have cloned and sequenced the human cyclin A gene and cDNAs representing its mRNAs and have characterized its promoter. Using synchronized cultures of NIH 3T3 cells stably transfected with cyclin A promoter/luciferase constructs, we show that the promoter is repressed during the G1 phase of the cell cycle and is activated at S-phase entry. Cell cycle regulation of the cyclin A gene promoter is mediated by sequences extending from -79 to +100 relative to the predominant transcription start site. It does not require the presence of a functional retinoblastoma protein. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1994-06-07
