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Human colon mucosal biofilms are carcinogenic in murine models

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA423288
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Organization of the microbiota was recently implicated in human CRC, with biofilm presence corresponding to a fivefold higher risk of CRC (Dejea et al. PNAS 2014). This project investigates the functional role of biofilm-associated bacteria from human CRC or healthy patients on CRC development through gnotobiotic and metagenomic approaches. Our project identifies a group of bacteria derived from biofilm-positive tissues that was associated with tumorigenesis in ApcMin/+ and ApcMin/+;Il10-/- mice.
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2017-12-20
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