Identification of different miRNAs in Alzheimer's disease and vascular cognitive impairment and dementia

There are many subtypes of dementia without any minimally invasive, low-cost and efficient diagnostic biomarkers. MicroRNA (miRNA) are easily gained and accessible from patients, which may be a promising biomarker for dementia diagnosis and differential diagnosis. We make a completely expression analysis of serum miRNA from 24 participants including post-stroke cognitive impairment (PSCI) group (n=6), post-stroke non-cognitive impairment (PSCI) group, Alzheimer's Disease (AD) group (n=6) and normal control group (NC) group (n=6). Different expression miRNA (DE -miRNA) were screened by LIMMA ebayes method, Benjamini-Hochberg check and fold change (P < 0.05, |log2FC|=1), we construct a DE-miRNA-key gene-signaling pathway network, the roles of DE-miRNA and related genes and signaling pathways in AD and PSCI were deduced through comprehensive network construction and literature search. Overall design: Totally, plasma of 24 patients who have been admitted to The Department of Neurology at the First Hospital of Jilin University between 2021 and 2022 were selected. We conduct a comprehensive miRNA expression analysis of plasma samples from group1:post-stroke cognitive impairment (PSCI) group (n=6), group 2: post-stroke non-cognitive impairment (PSCI) group, group 3: Alzheimer's Disease (AD) group (n=6) and group 4: normal control group (NC) group (n=6).