Determine whether differences in TLR-responsiveness alter susceptibility to Biodefense priority pathogens using WN virus as a paradigm or responsiveness to vaccination using influenza as a model shared to Semi-Public Workspace (SPW) Project

To assess the effects of the impairments in innate immunity identified in the study titled <i>Delineate innate immune responses in populations at risk (the elderly and the immunosuppressed) that are different from the general population</i> on the efficiency of the response to agents of Bioterrorism, using WN virus infection and influenza vaccination as models.<br><br>Will also assess these responses directly from patients who had WN virus infection or the influenza vaccine. Will elucidate mechanisms mediating innate immune responses to viral infection using murine models.