NTR-Bench: Release-aware temporal variation and provenance limits in a natural-product-defined bioactivity benchmark

NTR-Bench is the public reproducibility dataset and code package accompanying a release-aware analysis of temporal variation and provenance limits in a natural-product-defined bioactivity benchmark. It contains analysis-ready derived tables from ChEMBL-based historical and later-literature evidence, recorded-context comparability outputs, selection diagnostics, provenance-stress results, an exploratory evidence-accumulation analysis, a BindingDB cross-curation lane, compact Python reproduction scripts, source/version metadata, and licensing information. Raw third-party database snapshots are not redistributed. The portable workflow reproduces the manuscript's headline numerical results, including the 25,764-pair historical baseline, 769 recorded-context C1 pairs, median absolute temporal change of 0.509 pActivity, the 106-pair evidence-accumulation analysis, and the 214-pair BindingDB cross-curation analysis.