Base-Controlled Diastereoselective Synthesis of Either anti- or syn-β-Aminonitriles
收藏Figshare2017-03-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Base-Controlled_Diastereoselective_Synthesis_of_Either_i_anti_i_-_or_i_syn_i_-_-Aminonitriles/4768219
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Deprotonation of secondary alkane nitriles with nBuLi and addition to aryl imines gives kinetic anti-β-aminonitriles. Use of LHMDS allows reversible protonation of the reaction intermediate to give syn-β-aminonitriles. The pure diastereosiomers can be isolated in good yields, and the mechanism was elucidated.
创建时间：
2017-03-20
