Genotype, sex, and age-of-onset distribution for well-phenotyped case and control Leonbergers.

Top: CFA16 ARHGEF10 deletion genotyping of the original GWAS cohort, the larger, independent validation group, and all dogs combined. D/D = homozygous for the ARHGEF10 deletion. D/N = heterozygous for the ARHGEF10 deletion. N/N = homozygous normal. Each genotype group is further broken into sex and age-of-onset of clinical signs (either before or during the dog's third year, or after the dog's third year). Chi-square test of homogeneity p-values are reported for both genotypic and allelic frequencies (although these were calculated without using the sex or age-of-onset splits). Bottom: CFA7 TIGRP2P93473_rs9189862 SNP (located at Mb position 25,888,992) genotyping of the original GWAS cohort, and a combined cohort of all cases and controls meeting the inclusion criteria (GWAS dogs are included here). CFA: Canis lupus familiaris chromosome; GWAS: genome-wide association study.Genotype, sex, and age-of-onset distribution for well-phenotyped case and control Leonbergers.