Dietary Genistein Prevents Denervation-Induced Muscle Atrophy in Male Rodents via Effects on Estrogen Receptor-a.

Genistein intake significantly suppressed the loss of soleus muscle weight and the denervation-induced up-regulations of FOXO1 protein. The results of a DNA microarray showed that the estrogen receptor (ER) target genes are changed by genistein intake. Genistein suppressed the soleus muscle atrophy, and it was attenuated under the ER antagonist treatment. The administration of an ERa agonist suppressed the denervation-induced muscle atrophy and up-regulation of Atrogin1 gene expression, but the ERß agonist had no effect.染料木黄酮（Genistein）摄入可显著抑制比目鱼肌重量丢失，以及去神经支配诱导的FOXO1蛋白表达上调。DNA微阵列（DNA microarray）检测结果显示，染料木黄酮摄入会改变雌激素受体（ER）靶基因的表达水平。染料木黄酮可抑制比目鱼肌萎缩，且该抑制效应可被雌激素受体拮抗剂处理所削弱。给予雌激素受体α（ERα）激动剂可抑制去神经支配诱导的肌肉萎缩及Atrogin1基因表达上调，但雌激素受体β（ERβ）激动剂无此效果。