RNA-seq data from naturally-occurring early canine urothelial carcinoma detected through screening of dogs in a high-risk breed (Scottish Terriers)

Screening for urinary bladder cancer was performed in dogs in a breed (Scottish Terriers) with a very high inherited risk for bladder cancer. Naturally-occurring urothelial carcinoma in dogs serves as a relevant model for muscle invasive bladder cancer in humans. Urothelial carcinoma was detected in dogs with no outward evidence of the cancer. RNAseq data analyses were performed on these "early" tumors, and the sequencing files are included here. RNA-seq data from additional dogs has been deposited in the NCI Integrated Canine Data Commons (ICDC UBC02). Dogs were screened for bladder cancer with urinalysis and ultrasonography. Cystoscopic biopsies were collected from dogs wtih positive screening tests.