Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.
收藏PubMed Central1996-03-05 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC39941/
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资源简介：
Three of the predominant features of apoptosis are internucleosomal DNA fragmentation, plasma membrane bleb formation, and retraction of cell processes. We demonstrate that actin is a substrate for the proapoptotic cysteine protease interleukin 1beta-converting enzyme. Actin cleaved by interleukin 1beta-converting enzyme can neither inhibit DNase I nor polymerize to its filamentous form as effectively as intact actin. These findings suggest a mechanism for the coordination of the proteolytic, endonucleolytic, and morphogenetic aspects of apoptosis. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-03-05
