Expression data from renal fibrotic tissues in two rat models induced by unilateral ureteral obstruction (UUO) and adenine

Renal fibrosis (RF) is the common pathological outcome and central treatment target of multiple chronic kidney diseases. Currently, the molecular mechanisms of RF remain poorly understood. Therefore, this study aimed to established the adenine- and UUO-induced rat models, identified differentially expressed genes in their renal tissues using RNA-Seq analysis, and screened RF-related hub targets and key pathways.肾纤维化（Renal fibrosis, RF）是多种慢性肾脏疾病共有的病理结局与核心治疗靶点。目前，肾纤维化的分子机制仍未得到充分阐明。因此，本研究旨在构建腺嘌呤诱导及单侧输尿管梗阻（Unilateral Ureteral Obstruction, UUO）诱导的大鼠模型，通过RNA测序（RNA-Seq）分析鉴定其肾组织中的差异表达基因，并筛选出与RF相关的核心靶点与关键通路。