Nonsense Mediated mRNA decay mutes the splicing defects of spliceosome component mutations

The role of many splicing factors in pre-mRNA splicing and the involvement of these factors in the processing of specific transcripts have often been defined through the analysis of loss of function mutants in vivo众多剪接因子（splicing factors）在前mRNA（pre-mRNA）剪接中的作用，以及这些因子参与特定转录本加工的相关情况，通常可通过体内（in vivo）功能丧失突变体（loss of function mutants）的分析得到明确阐释。