Modeled proliferation rates for CD4+ T-cell subpopulations.

Values represent proportion of labeled cells newly generated per day, normalized for average glucose enrichment. CCR5− cells were sorted by CXCR4 expression in all HIV subjects (except RH01) but not in controls. n/a, data not available. HIV dynamic factor represents the mean proportional effect of HIV infection on turnover rates compared to controls. In order to avoid multiple comparisons, values for proliferation rate were only compared within corresponding cell-types between subject groups (control versus “All HIV-positive” subjects, not with separate HIV-positive subgroups),
†P<0.05 versus control subjects for CCR5+ and.
§P<0.05 for CCR5− cells, unpaired t-test; within cell-type between HIV groups (no significant differences); and between corresponding cell-types (chemokine receptor positive versus negative) within subject groups,
*P<0.05,
**P<0.01 CCR5+ versus CCR5− cells,
¶P<0.05 CXCR4+ versus CXCR4− CCR5− cells, paired t-tests.