File S1 - Exercise Challenge in Gulf War Illness Reveals Two Subgroups with Altered Brain Structure and Function

Figure A, Change in pain perception throughout the protocol. Figure B, Group averages for percentage correct on the 2-back working memory recall task before and after exercise. Figure C, Receiver Operator Curve for ΔDBP≥18 mm Hg after exercise. Table A, Subject demographics for controls and all Gulf War Illness subgroups. Table B, Timing of fMRI, dolorimetry, exercise tests, and orthostatic measurements. Table C, Absolute mean supine and standing measurements. Table D, Fisher's exact test for postural indices. Table E, Interoceptive complaints, chemical sensitivity questionnaires, and GAD-7. Table F, Interoceptive Global score. Table G, Chalder's Fatigue Score and it's Physical and Cognitive construct. Table H, MOS-SF-36 Quality of Life Domains for GWI subgroups and controls. Table I, Principal component analysis and Monte Carlo simulation to assess Chalder fatigue scores between START and STOPP subjects. Table J, Functional network for the 2-back WM paradigm before exercise. Table K, Significant regions of activations for direct multiple comparisons during the 2-back working memory paradigm before exercise. Table L, Functional network for the 2-back WM paradigm after exercise. Table M, Significant regions activated for direct multiple comparisons during the 2-back working memory paradigm after exercise. Table N, Mean Fractional Anisotropy (FA) Values for bilateral Superior Longitudinal Fasciculi. Table O, Significant grey matter and white matter volume reduction using VBM. Table P, Case definitions and potential consensus criteria. Table Q, Values for receiver operator curve (ROC). Table R, Model selection for mixed effects statistics. Table S, Type 3 analysis of deviance for change in heart rate by group and treatment. Table T, Post-hoc comparisons of heart rate data by patient group and treatment. (DOCX)