Transcriptomics of SARS-CoV-2’s coinfection potential: implications for the host targetome

SARS-CoV-2 coinfection with other pathogens and their interactions is increasingly recognized in the literature as potential determinants of COVID-19 phenotypes. A direct implication of this concept is whether and which co-pathogens function synergistically on the transcriptomic level with SARS-CoV-2. Using a list of differentially expressed genes following SARS-CoV-2 infection extracted, gene set enrichment analysis revealed HSV1, EBV, HIV1, IAV and Strep. Pneumoniae, among other pathogens (FDR<0.05). These results provide insight into the synergism between SARS-CoV-2 and other pathogens.