ZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia [ChIP-seq]
收藏NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE181617
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资源简介：
We report changes in chromatin occupancy dependent on TCF3-ZNF384 splicing isoform usage. The isoform including exon 8, which encodes 2 zinc finger domains, has increased binding near genes important for nomal hematopoiesis. We report no global changes in H3K27Ac upon expression of ZNF384 fusions but 47 loci with increased H3K27Ac. 4 replicates of HA-tagged fusion proteins expressed in ARF-null pre-B cells or 2 replicates of H3K27Ac in fusion-expressing or wildtype expressing cells.
创建时间：
2022-09-01
