miRNome and piRnome reveals new insights into the molecular biology of field cancerization in gastric cancer. Gastric Cancer Mirnome and piRnome on the cancerization field

MicroRNAs (miRNAs) and piRNAs play an important role in gastric carcinogenesis and have been associated with field cancerization in gastric cancer; however, the role of these molecules is not fully understood. We performed small non-coding RNAs sequencing of non-cancer, adjacent to tumor and gastric samples, to better understand the involvement of both miRNAs and piRNAs in gastric field cancerization. We analyzed samples of patients without cancer as control (non-cancer), adjacent to cancer and gastric cancer. Our results indicated that miRNAs and piRNAs have great accuracy in discriminating non-cancer from other tissues and can be potentially useful as biomarkers for gastric cancer.