Anti-Markovnikov Intermolecular Hydroamination: A Bis(amidate) Titanium Precatalyst for the Preparation of Reactive Aldimines

A bulky bis(N-2‘,6‘-diisopropylphenyl(phenyl)-amidate)titanium-bis(diethylamido) complex was identified as a highly active and regioselective
precatalyst for the anti-Markovnikov hydroamination of a wide range of terminal alkyl alkynes with alkylamines. This titanium complex was
fully characterized, including its X-ray crystal structure. The reactive aldimine products generated have been further elaborated using one-pot
procedures to give substituted amines, aldehydes, and the isoquinoline framework.