Transcriptomic analysis of Pot1a/b knockout in a native mouse model of glioma. Transcriptomic analysis of Pot1a/b knockout in a native mouse model of glioma

Please see the cited publication below for further details. This study found that Pot1a/b knockout in a native mouse model of glioma confers sexual dimorphism of survival and discovered sex-dependent changes in telomere content as well as signatures of immune infiltration and cell cycle in these tumors. Overall design: The native mouse model of glioma used in this study (C3 model) was generated via embryonic CRISPR/Cas9 knockout of Trp53, Nf1, and Pten. Additional CRISPR/Cas9 knockout of Pot1a and Pot1b resulted in the C5 model.