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Transcriptome Analysis of TubA Effects on Oocytes Development in Mice

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135003
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TubA is a specific inhibitor of HDAC6, it could regulate oocytes maturation by regulating acetylation of α-tubulin. However, weather it effects maternal mRNA expression remains unkown. Therefore, in this study,we got in vitro maturated MII oocytes in control and 0.1μg/mL treated .Our study suggests that TubA mainly downregulated cell cycle and DNA methylation related genes. single cell mRNA profiles of control and TubA treated MII oocytes were generated by deep sequencing, 5 samples for each group, using Illumina HiSeq 2000
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2022-01-02
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