Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress. Xi-He Qin et al.

Using RNA sequencing (RNA-seq), we found that hepatic arachidonic acid metabolism pathway, especially epoxyeicosatrienoic acids (EETs) signaling, was specifically altered following chronic mild stress (CMS) paradigm, a validated animal model employed to study the psychopathology of stress-related disorders including depression. Datasets include the unmodified gel and microscopy images for each figure, as well as all original data files generated by raw reads for RNA-seq.

通过RNA测序技术，本研究揭示肝细胞中花生四烯酸代谢途径，尤其是环氧二十碳三烯酸（EETs）信号传导，在慢性轻度应激（CMS）模型下发生显著改变。CMS模型作为一种经过验证的动物模型，常用于研究与压力相关的心理病理学疾病，包括抑郁症。数据集包括未经修改的凝胶和显微镜图像，以及由RNA测序原始读数生成的所有原始数据文件。