Peel-and-Swiss Roll Biopsy: A Practical Technique for Tissue Sampling in Fragile Blistering Skin Conditions

1. Video demonstration of the peel-and-Swiss roll biopsy technique, illustrating the atraumatic retrieval and preparation of a detached epidermal sheet for histopathological examination
2. Supplementary Fig 1. (A) Representative tissue sections from a patient with Staphylococcal scalded skin syndrome (SSSS), which shows a rolled-up, detached horny layer with mounds of parakeratosis (Hematoxylin and eosin, 100x), with (B) focal cluster of acantholytic cells (Hematoxylin and eosin, 400x).
3. Supplementary Fig 2. (A) Representative tissue sections from a patient with pemphigus vulgaris, showing “Swiss-roll” configuration at low-power magnification (Hematoxylin and eosin, 100x). (B) Intraepidermal separation with a blister roof and distinct acantholysis can be seen at high power view (Hematoxylin and eosin, 400x).