Expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice

Echinococcus multilocularis (Em) infection and the growth and proliferation of its metacestode within the liver of hosts are related to complex host–parasite interactions at the molecular level. However, the profiles of long non-coding RNAs (lncRNAs) and mRNAs of mice in response to Em are poorly understood. In this study, we detected numerous differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in the mouse liver at eight time points after Em infection. Some DEMs and DELs were found continuously dysregulated. These DEMs were notably enriched in the “antigen processing and presentation,” “Th1 and Th2 cell differentiation” and “Th17 cell differentiation” pathways. The profiles of long non-coding RNAs (lncRNAs) and mRNAs of mice in response to Em was measured at 2, 4, 8, 15, 30, 60, 90, 150 days post infection. Eight independent experiments were performed using CA group (n=4) and Con group (n=4) for each experiment.