RNA sequencing of subchondral bone from patients that underwent a joint replacement surgery due to osteoarthritis.

Osteoarthritis (OA) has a considerable genetic component. Genetic research has resulted in many insights into underlying disease pathways. Nonetheless, follow up studies of identified susceptibility genes towards underlying biological mechanisms, preclinical studies on target discovery and eventually drug testing during have thus far focused on gene expression profiling in articular cartilage. Therefore, the aim of the current study was to characterize pathophysiological processes of subchondral bone in human osteoarthritis (OA) in large human cohort RNA sequencing.EGA study EGAS00001004476