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Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs Endothelial Corneal Dystrophy

DataONE2025-06-11 更新2025-11-01 收录

细胞周期

Fuchs内皮角膜营养不良

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https://search.dataone.org/view/sha256:cbe238c74a359dcffd7e46b0649091019084177a0d1ccbb7d00ef4b88dbe17ba 数据链接链接失效反馈

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Graphpad file for statistics of Figure 1

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创建时间：

2025-10-29

DNA修复

细胞周期

The BRCA1 tumor suppressor plays an important role in homologous recombination (HR)-mediated DNA double-strand-break (DSB) repair. BRCA1 is phosphorylated by Chk2 kinase upon γ-irradiation, but the ro

DataCite Commons2020-09-04 更新120

Additional file 1: Table S1. of Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation

细胞周期

突变积累

Full results of pedigree-depth optimizations. Asterisks: control points that are fixed to constant values; LX-D: cell cycle length at distal end of DMMZ at stage LX (from L2 to L4 + 3 days); LX-P: cel

DataCite Commons2024-12-17 更新90

The requirement for cyclin E in c-Myc overexpressing breast cancers

乳腺癌

细胞周期

Basal-like triple-negative breast cancers frequently express high levels of c-Myc. This oncoprotein signals to the core cell cycle machinery by impinging on cyclin E. High levels of E-type cyclins (E1

DataCite Commons2024-02-23 更新80

Cell cycle distribution and EdU Index (Fig. 1F & Fig. S1B)

细胞周期

流式细胞术

uveniles were dissociated in pools of 15 polyps. Prior dissociation were labeled for 30 min with EdU (100uM, 2%DMSO) over several time points after feeding, and then dissociated and fixed using Trypsi

DataCite Commons2025-01-17 更新100

Data from: A robust and tunable mitotic oscillator in artificial cells

生物技术

细胞周期

Single-cell analysis is pivotal to deciphering complex phenomena like heterogeneity, bistability, and asynchronous oscillations, where a population ensemble cannot represent individual behaviors. Bulk

DataONE2018-04-20 更新80

Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs Endothelial Corneal Dystrophy

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