Cholesterol synthesis disorders

Cholesterol is synthesized via a cascade of enzymatic reactions known as the mevalonate pathway. This series of reactions is primarily regulated by a rate-limiting step involving the conversion of hydroxyl-methyl glutaryl-coenzyme A (HMG-CoA) into mevalonate. In this pathway multiple diseases and disorders involving the cholesterol synthesis are included and its role depicted in the pathway.

胆固醇的合成过程主要通过称为甲羟戊酸途径的一系列酶促反应实现。此系列反应主要由涉及羟基甲基戊二酰辅酶A（HMG-CoA）转化为甲羟戊酸的限速步骤进行调控。在此途径中，包括胆固醇合成在内的多种疾病和紊乱均被纳入，并在途径中描绘了其作用。