Integrated multilayer omics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart

This study using a system biology approach of transcriptomics, proteomics and metabolomics, we elucidated the role of endogenous histidyl dipeptides on cellular pathways and myocardial metabolism. Our multi-omics approach for the first-time unravels the landscape of genetic, proteomic, and metabolic changes influenced by histidyl di peptides. Gene expression comparison of mice with and without Carns transgenic. 8 samples were grouped into 2, WT and TG. Each group include 4 replicates.