WP4562 - Canonical NF-kB pathway - Homo sapiens
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The canonical NF-KB pathway is induced by the ligand-dependent activation of a variety of receptors. Stimulus-dependent activation of the IKK complex results in the phosphorylation and subsequent proteasomal degradation of IκBα and IκBε (NFKBIA and NFKBIE). This allows the nuclear translocation of transcriptionally active RelA/p50 (RELA, NFKB1) or c-Rel/p50 heterodimers (REL, NFKB1).
创建时间：
2025-04-17
