Therapeutic Potential of GPBAR1 Agonism in Primary Sclerosing Cholangitis (PSC)
收藏Mendeley Data2026-04-09 收录
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Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive biliary inflammation, fibrosis, and strictures, leading to liver cirrhosis and cholangiocarcinoma.
Despite advancements in understanding its pathogenesis, effective medical therapies are lacking. This study explores the therapeutic potential of GPBAR1 (also known as TGR5) agonism in PSC using the semisynthetic bile acid, BAR501.
