Effect of Mll3 deletion in MCF7 cells
收藏NIAID Data Ecosystem2026-04-30 收录
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资源简介：
MLL3 inactivation mutations occurs frequently in human breast cancer. To understand the function of MLL3 inactivation, we compared the gene expression profiles of the vector control (WT) and Mll3-knockout MCF7 cells generated by CRISPR-CAS9. Affymetrix human Gene 2.0ST arrays were used for microarray. To investigate the effect of MLL3 loss-of-function mutations on tumor cells, we deleted Mll3 in MCF7 cells with a lentiviral CRISPR vector. Total RNA was extracted from wild type (WT) and Mll3-Knockout MCF7 cells, and used for microarray analysis.
创建时间：
2023-01-07
