Gene expression changes of 4,4'-thiobis(6-tert-butyl-m-cresol)-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with 4,4'-thiobis(6-tert-butyl-m-cresol), and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在基于致癌物染毒大鼠的基因表达谱（gene expression profile），开发一种短期且高精度的肾脏致癌性（renal carcinogenicity）预测方法。本研究以4,4'-硫代双(6-叔丁基间甲酚)（4,4'-thiobis(6-tert-butyl-m-cresol)）处理雄性SD大鼠（SD rats），开展28天重复染毒实验（28 days-repeated dose experiments），并采用定制基因芯片（custom microarrays）分析大鼠肾皮质的基因表达谱。