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Expression data from BCL11A-null and wild-type bone marrow erythroid pregenitors. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA143187
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BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo for developmental silencing of gamma-globin genes in adult animals. We used microarray to determine the changes in gene expression profile after loss of BCL11A in adult erythroid cells Overall design: CD71+Ter119+ erythroid progenitor cells were FACS-sorted from bone marrows of 6-week old control (Bcl11a +/+) and BCL11A knockout (Bcl11a fl/fl EpoR-Cre+) mice.
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2012-03-22
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