Identification of osteoclast coupling factors in humans reveals links between bone remodeling and energy metabolism II
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=afaa7cc620ce3baf71190a98ab536982
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Purpose: Identification of osteoclast derived coupling factors using Denosumab as a biological probeMethod: harvested RNA from centrifuged bone biopsies (heterogeneous population containing bone lining cells, osteoblasts, osteoclasts and osteocytes, without in vitro cultureResults: Identification of genes differentially regulated in denosumab treated participants that correlate with bone remodeling indicesConclusions: Using this approach we identified denosumab regulated genes that correlate with bone remodeling in the untreated participants and may represent novel osteoclast derived coupling factors. Of interest, we identified DPP4 to be suppressed in denosumab treated participants, providing a novel link between bone remodeling and energy metabolism.
提供机构：
Mayo Clinic
创建时间：
2022-02-20
