Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase
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Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase Descriptor: CADMIUM ION, Dihydrofolate reductase, METHOTREXATE, ... Authors: Yachnin, B.J, Berghuis, A.M. Deposit date: 2008-09-15 Release date: 2009-05-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance. J.Biol.Chem., 284, 2009
创建时间：
2008-09-15
